This crawlspace in Kenton,OH had a moisture problem, which then led to a mold problem.
If you have a crawlspace under your home it is generally a good idea to open these vents to allow outside air to circulate under the floor in summer to prevent the moisture buildup that encourages mildew and rot. In winter, when the air is drier, the vents are closed to reduce the chance that the pipes in the crawl space might freeze.